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he Sunday Telegraph's cricket correspondent Scyld Berry reports that the 34-year-old will call time on his career "because his right knee makes it impossible for him to field all day and because he does not want to block the progress of some promising young batsmen in Yorkshire's side."
Vaughan has not featured for his country since stepping down as England captain following the third Test against South Africa at Edgbaston last summer, although he has continually stated his desire to feature again in the Ashes.
But England named a 16-man squad for an Ashes training camp and the three-day warm-up match against Warwickshire, which will form the basis of their selections for the five-Test Ashes series starting in Cardiff on July 8, without the Yorkshire batsman
It was the clearest signal yet he is unlikely to force his way back into England's plans.
Since the start of this summer, Vaughan has hardly pressed his case for a recall after scoring only 159 first class runs at an average of 19.88 this summer in six matches with a top score of 43 against Worcestershire last week.
He has also suffered a recurrence of the problems to his right knee which sidelined him for over a year and forced him to miss the recent Championship match with Somerset.